Read e-book online Advances in Immunology, Vol. 59 PDF

By Frank J. Dixon (Ed.)

ISBN-10: 0120224593

ISBN-13: 9780120224593

With contributions from Steven A. Porcelli and different across the world famous leaders within the box, this quantity maintains the culture of critical experiences. Papers at the CD1 kinfolk, confident choice of thymocytes, and molecular and mobile points of XLA spotlight the most recent quantity.

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Extra resources for Advances in Immunology, Vol. 59

Example text

Thus, it has been proposed that nonclassical MHC class I molecules lack polymorphism because they are no longer effective antigen-presenting molecules and, consequently, are not subject to continued positive selection for THE CD1 FAMILY 47 allelic variation (Klein and O’hUigin, 1994). This hypothesis leads to the conclusion that nonpolymorphic antigen-presenting molecules are no longer important in immune responses, although they may be retained because they provide a genetic substrate for further evolution of the MHC family.

2, reacts exclusively with denaturated CDld protein (Bilsland and Milstein, 1991). Because of the relatively large number of mAbs that have been generated against CDl, it has been possible to map specific serologically defined epitopes on these proteins by cross-inhibition studies. This approach confirms that the CDla, -b, and -c proteins as defined by mouse monoclonal antibodies are serologically very distinct. , 1987a). , 1987), but these have not been directly confirmed by other techniques. , 1985).

26 STEVEN A. PORCELLI domains of CD1, like the corresponding domains in MHC-encoded proteins, do not satisfy the criteria required for inclusion into the Ig superfamily. As is the case for MHC class I and 11, the evolutionary origin of these non-Ig-like domains is uncertain. Like all MHC class I a 2 domains and class I1 /3l domains, most CD1 a 2 domains also contain a pair of similarly spaced cysteine residues (shown at a 2 consensus positions 11and 76 in Fig. 3c), the one exception being mouse CDld2.

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Advances in Immunology, Vol. 59 by Frank J. Dixon (Ed.)

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